Nanoparticles as a solution against antibiotic resistance?

Scientists have succeeded in developing an efficient method to treat mucoviscidosis. Crucial are nanoparticles that transport the antibiotics more efficiently to their destination. First of all, the active particles need to have a certain size to be able to reach the deeper airways and not to bounce off somewhere else before. Ultimately, they have to penetrate the thick layer of mucus on the airways as well as the lower layers of the bacteria biofilm.

Nanoparticles as a possible solution to antibiotic resistance

Around one in 3,300 children in Germany is born with mucoviscidosis. A characteristic of this illness is that one channel albumen on the cell surface is disturbed by mutations. Thus, the amount of water of different secretions in the body is reduced, which creates a tough mucus. As a consequence, inner organs malfunction. Moreover, the mucus blocks the airways. Thus, the self-regulatory function of the lung is disturbed, the mucus is colonized by bacteria and chronic infections follow.